Transcription Factors

Transcription Factors

Transcription Factors Extra Levels of Control What? Transcription factors (TF) diffusible proteins

act at numerous sites on many chromosomes Influence transcription by interacting with other proteins or segments of DNA Upstream = being 5 to the start site Negative numbers of bases

Downstream = being 3 to the start site Positive numbers of bases Why? Finer control over transcription Recruits RNA Polymerase II

Selective expression of specific genes Protection of promoter sequences Protection from denaturation & proteolysis TATA box, upstream promoter element (UPE), Pribnow box, CpG islands, CAAT box, -10 to -35

Adoption of specific 3D conformation of DNA Upstream Promoter Element (UPE) Transcription Inhibition

Where?

Promoter & enhancer sequences on DNA On transcriptional elements (TE) or enhansons

In the open complex of DNA In the origin region of DNA In the helix-loop-helix motif In leucine zippers In zinc fingers

TATA box binding Zinc fingers Zinc Finger II

March 2007 Molecule of the Month by David Goodsell doi: 10.2210/rcsb_pdb/mom_2007_3 http://www.uic.edu/classes/bios/bios100/mike/spring2003/leucinezipper.jpg Helix-loop-helix

n0b311a.blogspot.com Helix-turn-helix FEMS Microbiology Reviews 29 (2005) 231262

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